Eugene d’Aquili and Andrew B. Newberg's The Mystical Mind: Probing the Biology of Religious Experience presents a core theory regarding the neurophysical nature of mystical experience; extensions of this theory, focusing upon near‐death experiences and the nature of religion itself; and buttressing arguments proposing that genetically based neurophysical “operators” within the brain compel human beings to think in certain ways. On the basis of this work, the authors pose a “metatheology,” suggesting that certain brain operations may underlie all the religions of the world. The core theory, its extensions, and related arguments are discussed in turn, concluding with commentary on the authors’ constructive theology.